Ductless, mini-split-systems make good retrofit add-ons to houses with “non-ducted” heating systems. They can also be a good choice for room additions where extending or installing distribution ductwork is not feasible, and very efficient new homes that require only a small space conditioning system. Be sure to choose an ENERGY STAR® compliant unit and hire an installer familiar with the product and its installation.

Like standard air-source heat pumps, mini splits have two main components — an outdoor compressor/condenser and an indoor air-handling unit. A conduit, which houses the power cable, refrigerant tubing, suction tubing, and a condensate drain, links the outdoor and indoor units.

The main advantages of mini splits are their small size and flexibility for zoning or heating and cooling individual rooms. Many models can have as many as four indoor air-handling units (for four zones or rooms) connected to one outdoor unit. The number depends on how much heating or cooling is required for the building or each zone (which in turn is affected by how well the building is insulated and air sealed). Each of the zones has its own thermostat, so you only need to condition occupied spaces. This will save energy and money.

The hook-up between the outdoor and indoor units generally requires only a three-inch hole through a wall for the conduit. Most manufacturers of this type of system can provide a variety of lengths of connecting conduits, and, if necessary, you can locate the outdoor unit as far away as 50 feet from the indoor evaporator. This makes it possible to cool rooms on the front side of a house, but locate the compressor in a more advantageous or inconspicuous place on the outside of the building.

Mini splits have no ducts, so they avoid the energy losses associated with the ductwork of central forced air systems. Duct losses can account for more than 30% of energy consumption for space conditioning, especially if the ducts are in an unconditioned space such as an attic.

In comparison to other add-on systems, mini splits offer more interior design flexibility. The indoor air handlers can be suspended from a ceiling, mounted flush into a drop ceiling, or hung on a wall. Floor-standing models are also available. Most indoor units are about seven inches deep and have sleek, high tech-looking jackets. Many also offer a remote control to make it easier to turn the system on and off when it’s positioned high on a wall or suspended from a ceiling.

Split systems can help keep your home safer, because there is only a small hole in the wall. Through-the-wall and window-mounted room air conditioners can provide easy access for intruders.

The cost of installing mini splits can be higher than some systems, although lower operating costs and rebates  — offered in some areas — can help offset the initial expense.  – excerpts from energy.gov